The Game About You -- based on an audio-only podcast -- requires a rewarding audio experience.
While Cecil isn't the player character, his presence in the game will be as ubiquitous as the radiation of the broadcast signals that carry Cecil's voice. As in the episode A Story About You, Cecil will narrate You's progress though the story. This allows the presence of the central character to the Night Vale franchise in what he does best: Narrate.
The system will be similar to that of the game Bastion with dynamic narration cues. The player's actions dictate the audio cues of Cecil's narration at times. However, the design can be conscious to disable the narration by turning off a radio or playing a scene where there is no radio.
The podcast uses music composed and performed by Disparition. The soundscape is very atmospheric and builds it's presence to what is paired with, rather than playing against it. It's important to establish a unique soundscape that isn't overpowering (unless it's SFX).
And now, the weather. Cecil Gershwin Palmer
"The Weather" is a feature of the podcast where a song from a recording artist is played. The song isn't custom to the episode, but usually matches the mood of the episode or of Night Vale itself. The Spotify playlist on this page includes the selection of songs from the podcast.
For "The Game About You," this tradition is continued by featuring a song introduced by Cecil when the story is best presented without narration, but a radio would still be in ear-shot.